Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTα impair enzymatic activity and fold stability

Antzeko izenburuak

• Interdomain communication in the phosphatidylcholine regulatory enzyme, CCTα, relies on a modular αE helix
  nork: Taneva, Svetla G., et al.
  Argitaratua: (2019)
• Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix
  nork: Lee, Jaeyong, et al.
  Argitaratua: (2014)
• Remodeling of the interdomain allosteric linker upon membrane binding of CCTα pulls its active site close to the membrane surface
  nork: Knowles, Daniel G., et al.
  Argitaratua: (2019)
• The Intrinsically Disordered Nuclear Localization Signal and Phosphorylation Segments Distinguish the Membrane Affinity of Two Cytidylyltransferase Isoforms
  nork: Dennis, Melissa K., et al.
  Argitaratua: (2011)
• Contribution of Each Membrane Binding Domain of the CTP:Phosphocholine Cytidylyltransferase-α Dimer to Its Activation, Membrane Binding, and Membrane Cross-bridging
  nork: Taneva, Svetla, et al.
  Argitaratua: (2008)