Converter domain mutations in myosin alter structural kinetics and motor function

Myosins are molecular motors that use a conserved ATPase cycle to generate force. We investigated two mutations in the converter domain of myosin V (R712G and F750L) to examine how altering specific structural transitions in the motor ATPase cycle can impair myosin mechanochemistry. The correspondin...

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Publicat a:J Biol Chem
Autors principals: Gunther, Laura K., Rohde, John A., Tang, Wanjian, Walton, Shane D., Unrath, William C., Trivedi, Darshan V., Muretta, Joseph M., Thomas, David D., Yengo, Christopher M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364761/
https://ncbi.nlm.nih.gov/pubmed/30518549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006128
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