Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

To define potentially causal variants for autoimmune disease, we fine-mapped(1,2) 76 rheumatoid arthritis (11,475 cases, 15,870 controls)(3) and type 1 diabetes loci (9,334 cases, 11,111 controls)(4). After sequencing 799 1-kilobase regulatory (H3K4me3) regions within these loci in 568 individuals,...

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Bibliografske podrobnosti
izdano v:Nat Genet
Main Authors: Westra, Harm-Jan, Martínez-Bonet, Marta, Onengut-Gumuscu, Suna, Lee, Annette, Luo, Yang, Teslovich, Nikola, Worthington, Jane, Martin, Javier, Huizinga, Tom, Klareskog, Lars, Rantapaa-Dahlqvist, Solbritt, Chen, Wei-Min, Quinlan, Aaron, Todd, John A., Eyre, Steve, Nigrovic, Peter A., Gregersen, Peter K., Rich, Stephen S., Raychaudhuri, Soumya
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364548/
https://ncbi.nlm.nih.gov/pubmed/30224649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0216-7
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