Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy

BACKGROUND: Gastrointestinal dysfunction can affect Parkinson’s disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the development of PD. Contrary to other animal models, the human A53T alpha-synuc...

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Detalhes bibliográficos
Publicado no:Transl Neurodegener
Main Authors: Rota, Lucia, Pellegrini, Carolina, Benvenuti, Laura, Antonioli, Luca, Fornai, Matteo, Blandizzi, Corrado, Cattaneo, Antonino, Colla, Emanuela
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364448/
https://ncbi.nlm.nih.gov/pubmed/30774946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-019-0146-z
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