Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

BACKGROUND: Melanoma is the most aggressive and deadly form of skin cancer with increasing case numbers worldwide. The development of inhibitors targeting mutated BRAF (found in around 60% of melanoma patients) has markedly improved overall survival of patients with late-stage tumors, even more so w...

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Margue, Christiane, Philippidou, Demetra, Kozar, Ines, Cesi, Giulia, Felten, Paul, Kulms, Dagmar, Letellier, Elisabeth, Haan, Claude, Kreis, Stephanie
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364417/
https://ncbi.nlm.nih.gov/pubmed/30728057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1038-x
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