A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells

BACKGROUND: Drug resistance remains an unsolved clinical issue in oncology. Despite promising initial responses obtained with BRAF and MEK kinase inhibitors, resistance to treatment develops within months in virtually all melanoma patients. METHODS: Microarray analyses were performed in BRAF inhibit...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Cesi, Giulia, Philippidou, Demetra, Kozar, Ines, Kim, Yeoun Jin, Bernardin, Francois, Van Niel, Guillaume, Wienecke-Baldacchino, Anke, Felten, Paul, Letellier, Elisabeth, Dengler, Sonja, Nashan, Dorothee, Haan, Claude, Kreis, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172729/
https://ncbi.nlm.nih.gov/pubmed/30290811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0886-x
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