A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells

BACKGROUND: Drug resistance remains an unsolved clinical issue in oncology. Despite promising initial responses obtained with BRAF and MEK kinase inhibitors, resistance to treatment develops within months in virtually all melanoma patients. METHODS: Microarray analyses were performed in BRAF inhibit...

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Bibliografski detalji
Izdano u:Mol Cancer
Glavni autori: Cesi, Giulia, Philippidou, Demetra, Kozar, Ines, Kim, Yeoun Jin, Bernardin, Francois, Van Niel, Guillaume, Wienecke-Baldacchino, Anke, Felten, Paul, Letellier, Elisabeth, Dengler, Sonja, Nashan, Dorothee, Haan, Claude, Kreis, Stephanie
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172729/
https://ncbi.nlm.nih.gov/pubmed/30290811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0886-x
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