SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis

Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors. Recent results show that SIX1 also acts as a repressor of cell senescence, an antiproliferative response with a key role in tumor suppression, among other physiological and pathological settings. Here, we set...

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Publicat a:Sci Rep
Autors principals: De Lope, Cristina, Martín-Alonso, Samara, Auzmendi-Iriarte, Jaione, Escudero, Carmen, Mulet, Isabel, Larrasa-Alonso, Javier, López-Antona, Irene, Matheu, Ander, Palmero, Ignacio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363751/
https://ncbi.nlm.nih.gov/pubmed/30723235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38176-0
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