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The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes
Cellular senescence is an antiproliferative response with essential functions in tumor suppression and tissue homeostasis. Here we show that SIX1, a member of the SIX family of homeobox transcriptional factors, is a novel repressor of senescence. Our data show that SIX1 is specifically downregulated...
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| Publié dans: | Oncogene |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5730042/ https://ncbi.nlm.nih.gov/pubmed/26500063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.408 |
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