Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells

Many adult tissues contain postmitotic cells as old as the host organism. The only organelle that does not turn over in these cells is the nucleus, and its maintenance represents a formidable challenge, as it harbors regulatory proteins that persist throughout adulthood. Here we developed strategies...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Principais autores: Toyama, Brandon H., Arrojo e Drigo, Rafael, Lev-Ram, Varda, Ramachandra, Ranjan, Deerinck, Thomas J., Lechene, Claude, Ellisman, Mark H., Hetzer, Martin W.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363465/
https://ncbi.nlm.nih.gov/pubmed/30552100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201809123
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