3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

3K3A-activated protein C (APC), a cell-signaling analogue of endogenous blood serine protease APC, exerts vasculoprotective, neuroprotective, and anti-inflammatory activities in rodent models of stroke, brain injury, and neurodegenerative disorders. 3K3A-APC is currently in development as a neuropro...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Lazic, Divna, Sagare, Abhay P., Nikolakopoulou, Angeliki M., Griffin, John H., Vassar, Robert, Zlokovic, Berislav V.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363429/
https://ncbi.nlm.nih.gov/pubmed/30647119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181035
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