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3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice
3K3A-activated protein C (APC), a cell-signaling analogue of endogenous blood serine protease APC, exerts vasculoprotective, neuroprotective, and anti-inflammatory activities in rodent models of stroke, brain injury, and neurodegenerative disorders. 3K3A-APC is currently in development as a neuropro...
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| Publicado no: | J Exp Med |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363429/ https://ncbi.nlm.nih.gov/pubmed/30647119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181035 |
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