FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Protective signaling from the leukemia microenvironment leads to leukemia cell persistence, development of resistance, and disease relapse. Here, we demonstrate that fibroblast growth factor 2 (FGF2) from bone marrow stromal cells is secreted in exosomes, which are subsequently endocytosed by leukem...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Javidi-Sharifi, Nathalie, Martinez, Jacqueline, English, Isabel, Joshi, Sunil K, Scopim-Ribeiro, Renata, Viola, Shelton K, Edwards, David K, Agarwal, Anupriya, Lopez, Claudia, Jorgens, Danielle, Tyner, Jeffrey W, Druker, Brian J, Traer, Elie
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363389/
https://ncbi.nlm.nih.gov/pubmed/30720426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40033
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