FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Protective signaling from the leukemia microenvironment leads to leukemia cell persistence, development of resistance, and disease relapse. Here, we demonstrate that fibroblast growth factor 2 (FGF2) from bone marrow stromal cells is secreted in exosomes, which are subsequently endocytosed by leukem...

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Veröffentlicht in:eLife
Hauptverfasser: Javidi-Sharifi, Nathalie, Martinez, Jacqueline, English, Isabel, Joshi, Sunil K, Scopim-Ribeiro, Renata, Viola, Shelton K, Edwards, David K, Agarwal, Anupriya, Lopez, Claudia, Jorgens, Danielle, Tyner, Jeffrey W, Druker, Brian J, Traer, Elie
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363389/
https://ncbi.nlm.nih.gov/pubmed/30720426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40033
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