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Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production
Human MondoA requires glucose as well as other modulatory signals to function in transcription. One such signal is acidosis, which increases MondoA activity and also drives a protective gene signature in breast cancer. How low pH controls MondoA transcriptional activity is unknown. We found that low...
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| Publicado no: | eLife |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363388/ https://ncbi.nlm.nih.gov/pubmed/30717828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40199 |
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