Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA

Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast cancer cells in response to three distinct tumor mic...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Julia Ling-Yu, Merl, Daniel, Peterson, Christopher W., Wu, Jianli, Liu, Patrick Yantyng, Yin, Hanwei, Muoio, Deborah M., Ayer, Don E., West, Mike, Chi, Jen-Tsan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937306/
https://ncbi.nlm.nih.gov/pubmed/20844768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001093
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