Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA

Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast cancer cells in response to three distinct tumor mic...

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Detalhes bibliográficos
Main Authors: Chen, Julia Ling-Yu, Merl, Daniel, Peterson, Christopher W., Wu, Jianli, Liu, Patrick Yantyng, Yin, Hanwei, Muoio, Deborah M., Ayer, Don E., West, Mike, Chi, Jen-Tsan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937306/
https://ncbi.nlm.nih.gov/pubmed/20844768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001093
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