Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells

BACKGROUND: Previous research has elucidated the signals required to induce nephron progenitor cells (NPCs) from pluripotent stem cells (PSCs), enabling the generation of kidney organoids. However, selectively controlling differentiation of NPCs to podocytes has been a challenge. METHODS: We investi...

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發表在:J Am Soc Nephrol
Main Authors: Yoshimura, Yasuhiro, Taguchi, Atsuhiro, Tanigawa, Shunsuke, Yatsuda, Junji, Kamba, Tomomi, Takahashi, Satoru, Kurihara, Hidetake, Mukoyama, Masashi, Nishinakamura, Ryuichi
格式: Artigo
語言:Inglês
出版: American Society of Nephrology 2019
主題:
Basic Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362617/
https://ncbi.nlm.nih.gov/pubmed/30635375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018070747
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