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New Therapeutic Targets for Alpha-1 Antitrypsin Deficiency
Alpha-1antitrypsin deficiency (AATD) results from the intracellular polymerization and retention of mutant alpha-1antitrypsin (AAT) within the endoplasmic reticulum of hepatocytes. This causes cirrhosis whilst the deficiency of circulating AAT predisposes to early onset emphysema. This is an excitin...
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| Publicado no: | Chronic Obstr Pulm Dis |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
COPD Foundation Inc
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6361470/ https://ncbi.nlm.nih.gov/pubmed/30723781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15326/jcopdf.5.4.2017.0165 |
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