Haploinsufficiency for SIX2 increases nephron progenitor proliferation leading to elevated branching and nephron number.

The regulation of final nephron number in the kidney is poorly understood. However, cessation of nephron formation occurs when the self-renewing nephron progenitor population commits to differentiation. Transcription factors within this progenitor population, such as SIX2, are assumed to control exp...

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Bibliografski detalji
Izdano u:Kidney Int
Glavni autori: Combes, Alexander N., Wilson, Sean, Phipson, Belinda, Binnie, Brandon B., Ju, Adler, Lawlor, Kynan T., Cebrian, Cristina, Walton, Sarah L., Smyth, Ian M., Moritz, Karen M., Kopan, Raphael, Oshlack, Alicia, Little, Melissa H.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361385/
https://ncbi.nlm.nih.gov/pubmed/29217079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.09.015
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