Uncovering the essential genome of the human malaria parasite Plasmodium falciparum by saturation mutagenesis

Severe malaria is caused by the apicomplexan parasite Plasmodium falciparum. Despite decades of research the unique biology of these parasites has made it challenging to establish high throughput genetic approaches for identification of therapeutic targets. Using transposon mutagenesis of P. falcipa...

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Vydáno v:Science
Hlavní autoři: Zhang, Min, Wang, Chengqi, Otto, Thomas D., Oberstaller, Jenna, Liao, Xiangyun, Adapa, Swamy R., Udenze, Kenneth, Bronner, Iraad F., Cassandra, Deborah, Mayho, Matthew, Brown, Jacqueline, Li, Suzanne, Swanson, Justin, Rayner, Julian C., Jiang, Rays H. Y., Adams, John H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360947/
https://ncbi.nlm.nih.gov/pubmed/29724925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aap7847
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