Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly affecting immune activation. A classic response to proinflammatory activation is increased flux through glycolysis with a downregulation of oxidative metabolism, whereas alternative activation is primarily oxida...

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Dades bibliogràfiques
Publicat a:J Immunol
Autors principals: Freemerman, Alex J., Zhao, Liyang, Pingili, Ajeeth K., Teng, Bin, Cozzo, Alyssa J., Fuller, Ashley M., Johnson, Amy R., Milner, J. Justin, Lim, Maili F., Galanko, Joseph A., Beck, Melinda A., Bear, James E., Rotty, Jeremy D., Bezavada, Lavanya, Smallwood, Heather S., Puchowicz, Michelle A., Liu, Juan, Locasale, Jason W., Lee, Douglas P., Bennett, Brian J., Abel, E. Dale, Rathmell, Jeff C., Makowski, Liza
Format: Artigo
Idioma:Inglês
Publicat: AAI 2019
Matèries:
Systems Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360258/
https://ncbi.nlm.nih.gov/pubmed/30659108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800002
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