Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly affecting immune activation. A classic response to proinflammatory activation is increased flux through glycolysis with a downregulation of oxidative metabolism, whereas alternative activation is primarily oxida...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Freemerman, Alex J., Zhao, Liyang, Pingili, Ajeeth K., Teng, Bin, Cozzo, Alyssa J., Fuller, Ashley M., Johnson, Amy R., Milner, J. Justin, Lim, Maili F., Galanko, Joseph A., Beck, Melinda A., Bear, James E., Rotty, Jeremy D., Bezavada, Lavanya, Smallwood, Heather S., Puchowicz, Michelle A., Liu, Juan, Locasale, Jason W., Lee, Douglas P., Bennett, Brian J., Abel, E. Dale, Rathmell, Jeff C., Makowski, Liza
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2019
Assuntos:
Systems Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360258/
https://ncbi.nlm.nih.gov/pubmed/30659108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800002
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