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Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model

An increasing number of G protein-coupled receptors (GPCRs) have been reported to be expressed in the plasma membrane as dimers. Since most ligand binding data are currently fitted by classical equations developed only for monomeric receptors, the interpretation of data could be misleading in the pr...

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Detalhes bibliográficos
Publicado no:Pharmacol Res
Main Authors: Casadó-Anguera, Verònica, Moreno, Estefanía, Mallol, Josefa, Ferré, Sergi, Canela, Enric I., Cortés, Antoni, Casadó, Vicent
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360119/
https://ncbi.nlm.nih.gov/pubmed/30472462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2018.11.032
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