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Arrested developments: CDK4/6 inhibitor resistance and alterations in the tumor immune microenvironment
The uncontrolled proliferation of cancer cells has led to the development of small molecule inhibitors to target cell cycle progression. Palbociclib, ribociclib and abemaciclib are ATP-competitive inhibitors of cyclin-dependent kinases 4/6 (CDK4/6), which function early within the G1 phase of the ce...
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| Publicado no: | Clin Cancer Res |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6359975/ https://ncbi.nlm.nih.gov/pubmed/30287548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1967 |
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