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Polygenic risk score increases schizophrenia liability through cognition-relevant pathways

Cognitive deficit is thought to represent, at least in part, genetic mechanisms of risk for schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct causality from the former to the latter. However, earlier evidence was based on inferences from twin not molecular...

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Détails bibliographiques
Publié dans:Brain
Auteurs principaux: Toulopoulou, Timothea, Zhang, Xiaowei, Cherny, Stacey, Dickinson, Dwight, Berman, Karen F, Straub, Richard E, Sham, Pak, Weinberger, Daniel R
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359897/
https://ncbi.nlm.nih.gov/pubmed/30535067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy279
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