Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

BACKGROUND: Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset Alzheimer’s disease (LOAD). Amongst these, a polymorphism in phospholipase C-gamma 2 (PLCG2) P522R has been reported to be protective against LOAD. PLC enzy...

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Vydáno v:Alzheimers Res Ther
Hlavní autoři: Magno, Lorenza, Lessard, Christian B., Martins, Marta, Lang, Verena, Cruz, Pedro, Asi, Yasmine, Katan, Matilda, Bilsland, Jamie, Lashley, Tammaryn, Chakrabarty, Paramita, Golde, Todd E., Whiting, Paul J.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359863/
https://ncbi.nlm.nih.gov/pubmed/30711010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0469-0
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