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Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations
The feasibility of upscaling the formulation of co-amorphous indomethacin-lysine from lab-scale to pilot-scale spray drying was investigated. A 2(2) full factorial design of experiments (DoE) was employed at lab scale. The atomization gas flow rate (F(atom), from 0.5 to 1.4 kg/h) and outlet temperat...
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| 出版年: | Pharmaceutics |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6358949/ https://ncbi.nlm.nih.gov/pubmed/30634423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11010024 |
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