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Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations

The feasibility of upscaling the formulation of co-amorphous indomethacin-lysine from lab-scale to pilot-scale spray drying was investigated. A 2(2) full factorial design of experiments (DoE) was employed at lab scale. The atomization gas flow rate (F(atom), from 0.5 to 1.4 kg/h) and outlet temperat...

詳細記述

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書誌詳細
出版年:Pharmaceutics
主要な著者: Kasten, Georgia, Duarte, Íris, Paisana, Maria, Löbmann, Korbinian, Rades, Thomas, Grohganz, Holger
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358949/
https://ncbi.nlm.nih.gov/pubmed/30634423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11010024
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