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Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations

The feasibility of upscaling the formulation of co-amorphous indomethacin-lysine from lab-scale to pilot-scale spray drying was investigated. A 2(2) full factorial design of experiments (DoE) was employed at lab scale. The atomization gas flow rate (F(atom), from 0.5 to 1.4 kg/h) and outlet temperat...

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Bibliografiske detaljer
Udgivet i:Pharmaceutics
Main Authors: Kasten, Georgia, Duarte, Íris, Paisana, Maria, Löbmann, Korbinian, Rades, Thomas, Grohganz, Holger
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358949/
https://ncbi.nlm.nih.gov/pubmed/30634423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11010024
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