Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

A variety of natural compounds have been shown to modulate T cell receptor (TCR) activation, including natural sesquiterpene lactones (SLs). In the present studies, we evaluated the biological activity of 11 novel semi-synthetic SLs to determine their ability to modulate TCR activation. Of these com...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Molecules
Auteurs principaux: Khlebnikov, Andrei I., Schepetkin, Igor A., Kishkentaeva, Anarkul S., Shaimerdenova, Zhanar R., Atazhanova, Gayane A., Adekenov, Sergazy M., Kirpotina, Liliya N., Quinn, Mark T.
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358946/
https://ncbi.nlm.nih.gov/pubmed/30669433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24020350
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires