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A folding switch regulates interleukin 27 biogenesis and secretion of its α-subunit as a cytokine
A common design principle of heteromeric signaling proteins is the use of shared subunits. This allows encoding of complex messages while maintaining evolutionary flexibility. How cells regulate and control assembly of such composite signaling proteins remains an important open question. An example...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6358668/ https://ncbi.nlm.nih.gov/pubmed/30651310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816698116 |
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