Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

OBJECTIVE: Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. METHODS: A series of peptide-based GIP analogs, including structurally diverse agonists and a long-acting antagonist, were generated...

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Publicat a:Mol Metab
Autors principals: Mroz, Piotr A., Finan, Brian, Gelfanov, Vasily, Yang, Bin, Tschöp, Matthias H., DiMarchi, Richard D., Perez-Tilve, Diego
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358549/
https://ncbi.nlm.nih.gov/pubmed/30578168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.12.001
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