Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

OBJECTIVE: Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. METHODS: A series of peptide-based GIP analogs, including structurally diverse agonists and a long-acting antagonist, were generated...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Mol Metab
Hoofdauteurs: Mroz, Piotr A., Finan, Brian, Gelfanov, Vasily, Yang, Bin, Tschöp, Matthias H., DiMarchi, Richard D., Perez-Tilve, Diego
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2018
Onderwerpen:
Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358549/
https://ncbi.nlm.nih.gov/pubmed/30578168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.12.001
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items