Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes

OBJECTIVE: Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) of ani...

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Bibliografiske detaljer
Udgivet i:Mol Metab
Main Authors: Aghanoori, Mohamad-Reza, Smith, Darrell R., Shariati-Ievari, Shiva, Ajisebutu, Andrew, Nguyen, Annee, Desmond, Fiona, Jesus, Carlos H.A., Zhou, Xiajun, Calcutt, Nigel A., Aliani, Michel, Fernyhough, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358538/
https://ncbi.nlm.nih.gov/pubmed/30545741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.11.008
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