Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

The muscarinic acetylcholine type 1 receptor (M(1)R) is a metabotropic G protein-coupled receptor. Knockout of M(1)R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested...

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Vydáno v:Front Neurosci
Hlavní autoři: Sabbir, Mohammad G., Calcutt, Nigel A., Fernyhough, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029366/
https://ncbi.nlm.nih.gov/pubmed/29997469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00402
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