Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

The muscarinic acetylcholine type 1 receptor (M(1)R) is a metabotropic G protein-coupled receptor. Knockout of M(1)R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested...

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Udgivet i:Front Neurosci
Main Authors: Sabbir, Mohammad G., Calcutt, Nigel A., Fernyhough, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029366/
https://ncbi.nlm.nih.gov/pubmed/29997469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00402
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