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Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

The muscarinic acetylcholine type 1 receptor (M(1)R) is a metabotropic G protein-coupled receptor. Knockout of M(1)R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Sabbir, Mohammad G., Calcutt, Nigel A., Fernyhough, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029366/
https://ncbi.nlm.nih.gov/pubmed/29997469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00402
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