Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

The muscarinic acetylcholine type 1 receptor (M(1)R) is a metabotropic G protein-coupled receptor. Knockout of M(1)R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested...

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Bibliografische gegevens
Gepubliceerd in:Front Neurosci
Hoofdauteurs: Sabbir, Mohammad G., Calcutt, Nigel A., Fernyhough, Paul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029366/
https://ncbi.nlm.nih.gov/pubmed/29997469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00402
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