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Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons
The muscarinic acetylcholine type 1 receptor (M(1)R) is a metabotropic G protein-coupled receptor. Knockout of M(1)R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested...
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| Опубликовано в: : | Front Neurosci |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6029366/ https://ncbi.nlm.nih.gov/pubmed/29997469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00402 |
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