Chemoenzymatic Synthesis of Trehalosamine, an Aminoglycoside Antibiotic and Precursor to Mycobacterial Imaging Probes

Trehalosamine (2-amino-2-deoxy-α,α-D-trehalose) is an aminoglycoside with antimicrobial activity against Mycobacterium tuberculosis, and it is also a versatile synthetic intermediate used to access imaging probes for mycobacteria. To overcome inefficient chemical synthesis approaches, we report a 2-...

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Bibliografiska uppgifter
I publikationen:J Org Chem
Huvudupphovsmän: Groenevelt, Jessica M., Meints, Lisa M., Stothard, Alicyn I., Poston, Anne W., Fiolek, Taylor J., Finocchietti, David H., Mulholand, Victoria M., Woodruff, Peter J., Swarts, Benjamin M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358420/
https://ncbi.nlm.nih.gov/pubmed/29973045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b00810
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