Nuclear phospholipase C isoenzyme imbalance leads to pathologies in brain, hematologic, neuromuscular, and fertility disorders

Phosphoinositide-specific phospholipases C (PI-PLCs) are involved in signaling pathways related to critical cellular functions, such as cell cycle regulation, cell differentiation, and gene expression. Nuclear PI-PLCs have been studied as key enzymes, molecular targets, and clinical prognostic/diagn...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Ratti, Stefano, Follo, Matilde Y., Ramazzotti, Giulia, Faenza, Irene, Fiume, Roberta, Suh, Pann-Ghill, McCubrey, James A., Manzoli, Lucia, Cocco, Lucio
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Thematic Review Series: The Role of Phosphoinositides in Signaling and Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358293/
https://ncbi.nlm.nih.gov/pubmed/30287524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R089763
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