Ubiquitination of Rheb governs growth factor-induced mTORC1 activation

Mechanistic target of rapamycin mTOR complex 1 (mTORC1) plays a key role in the integration of various environmental signals to regulate cell growth and metabolism. mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase. However, the regulatory mechan...

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Bibliografske podrobnosti
izdano v:Cell Res
Main Authors: Deng, Lu, Chen, Lei, Zhao, Linlin, Xu, Yan, Peng, Xiaoping, Wang, Xinbo, Ding, Lin, Jin, Jiali, Teng, Hongqi, Wang, Yanming, Pan, Weijuan, Yu, Fei, Liao, Lujian, Li, Li, Ge, Xin, Wang, Ping
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355928/
https://ncbi.nlm.nih.gov/pubmed/30514904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0120-9
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