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Promoter-proximal pausing mediated by the exon junction complex regulates splicing
Promoter-proximal pausing of RNA polymerase II (Pol II) is a widespread transcriptional regulatory step across metazoans. Here we find that the nuclear exon junction complex (pre-EJC) is a critical and conserved regulator of this process. Depletion of pre-EJC subunits leads to a global decrease in P...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355915/ https://ncbi.nlm.nih.gov/pubmed/30705266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08381-0 |
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