Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors

Normal cells become cancer cells after a malignant transformation, but whether cancer cells can be reversed to normal status remains elusive. Here, we report that the combination of hepatocyte nuclear factor 1A (HNF1A), HNF4A and forkhead box protein A3 (FOXA3) synergistically reprograms hepatocellu...

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Publicado en:Cell Res
Main Authors: Cheng, Zhuo, He, Zhiying, Cai, Yongchao, Zhang, Cheng, Fu, Gongbo, Li, Hengyu, Sun, Wen, Liu, Changcheng, Cui, Xiuliang, Ning, Beifang, Xiang, Daimin, Zhou, Tengfei, Li, Xiaofeng, Xie, Weifen, Wang, Hongyang, Ding, Jin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355772/
https://ncbi.nlm.nih.gov/pubmed/30560924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0111-x
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