Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors

Normal cells become cancer cells after a malignant transformation, but whether cancer cells can be reversed to normal status remains elusive. Here, we report that the combination of hepatocyte nuclear factor 1A (HNF1A), HNF4A and forkhead box protein A3 (FOXA3) synergistically reprograms hepatocellu...

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Publicat a:Cell Res
Autors principals: Cheng, Zhuo, He, Zhiying, Cai, Yongchao, Zhang, Cheng, Fu, Gongbo, Li, Hengyu, Sun, Wen, Liu, Changcheng, Cui, Xiuliang, Ning, Beifang, Xiang, Daimin, Zhou, Tengfei, Li, Xiaofeng, Xie, Weifen, Wang, Hongyang, Ding, Jin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355772/
https://ncbi.nlm.nih.gov/pubmed/30560924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0111-x
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