Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies. Currently, we do not know the biological mechanisms that explain the variability in clinical responses in HLA alloimmunized pati...

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Udgivet i:Haematologica
Main Authors: Rijkers, Maaike, Schmidt, David, Lu, Nina, Kramer, Cynthia S.M., Heidt, Sebastiaan, Mulder, Arend, Porcelijn, Leendert, Claas, Frans H.J., Leebeek, Frank W.G., Jansen, A.J. Gerard, Jongerius, Ilse, Zeerleder, Sacha S., Vidarsson, Gestur, Voorberg, Jan, de Haas, Masja
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355480/
https://ncbi.nlm.nih.gov/pubmed/30262558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.201665
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