Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury

Tumor cure with conventional fractionated radiotherapy is 65%, dependent on tumor cell–autonomous gradual buildup of DNA double-strand break (DSB) misrepair. Here we report that single-dose radiotherapy (SDRT), a disruptive technique that ablates more than 90% of human cancers, operates a distinct d...

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Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Bodo, Sahra, Campagne, Cécile, Thin, Tin Htwe, Higginson, Daniel S., Vargas, H. Alberto, Hua, Guoqiang, Fuller, John D., Ackerstaff, Ellen, Russell, James, Zhang, Zhigang, Klingler, Stefan, Cho, HyungJoon, Kaag, Matthew G., Mazaheri, Yousef, Rimner, Andreas, Manova-Todorova, Katia, Epel, Boris, Zatcky, Joan, Cleary, Cristian R., Rao, Shyam S., Yamada, Yoshiya, Zelefsky, Michael J., Halpern, Howard J., Koutcher, Jason A., Cordon-Cardo, Carlos, Greco, Carlo, Haimovitz-Friedman, Adriana, Sala, Evis, Powell, Simon N., Kolesnick, Richard, Fuks, Zvi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355243/
https://ncbi.nlm.nih.gov/pubmed/30480549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97631
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