Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury

Tumor cure with conventional fractionated radiotherapy is 65%, dependent on tumor cell–autonomous gradual buildup of DNA double-strand break (DSB) misrepair. Here we report that single-dose radiotherapy (SDRT), a disruptive technique that ablates more than 90% of human cancers, operates a distinct d...

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Vydáno v:J Clin Invest
Hlavní autoři: Bodo, Sahra, Campagne, Cécile, Thin, Tin Htwe, Higginson, Daniel S., Vargas, H. Alberto, Hua, Guoqiang, Fuller, John D., Ackerstaff, Ellen, Russell, James, Zhang, Zhigang, Klingler, Stefan, Cho, HyungJoon, Kaag, Matthew G., Mazaheri, Yousef, Rimner, Andreas, Manova-Todorova, Katia, Epel, Boris, Zatcky, Joan, Cleary, Cristian R., Rao, Shyam S., Yamada, Yoshiya, Zelefsky, Michael J., Halpern, Howard J., Koutcher, Jason A., Cordon-Cardo, Carlos, Greco, Carlo, Haimovitz-Friedman, Adriana, Sala, Evis, Powell, Simon N., Kolesnick, Richard, Fuks, Zvi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355243/
https://ncbi.nlm.nih.gov/pubmed/30480549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97631
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