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Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia
The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive target for immunotherapy, since it is an essential driver gene and 4 bp frameshift insertions occur in the same hotspot in 30%–35% of AMLs, resu...
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| Опубликовано в: : | J Clin Invest |
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| Главные авторы: | , , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355238/ https://ncbi.nlm.nih.gov/pubmed/30640174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97482 |
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