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Transcription factor mutations as a cause of familial myeloid neoplasms

The initiation and evolution of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are driven by genomic events that disrupt multiple genes controlling hematopoiesis. Human genetic studies have discovered germline mutations in single genes that instigate familial MDS/AML. The best under...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Churpek, Jane E., Bresnick, Emery H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355228/
https://ncbi.nlm.nih.gov/pubmed/30707109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120854
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