Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma mansoni as proof of principle. This secreted ribonuclease is crucial for Th2 polarization and granuloma formation. Schistosome eggs were exposed...

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Publicat a:eLife
Autors principals: Ittiprasert, Wannaporn, Mann, Victoria H, Karinshak, Shannon E, Coghlan, Avril, Rinaldi, Gabriel, Sankaranarayanan, Geetha, Chaidee, Apisit, Tanno, Toshihiko, Kumkhaek, Chutima, Prangtaworn, Pannathee, Mentink-Kane, Margaret M, Cochran, Christina J, Driguez, Patrick, Holroyd, Nancy, Tracey, Alan, Rodpai, Rutchanee, Everts, Bart, Hokke, Cornelis H, Hoffmann, Karl F, Berriman, Matthew, Brindley, Paul J
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Microbiology and Infectious Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355194/
https://ncbi.nlm.nih.gov/pubmed/30644357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41337
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