Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1

Mechanisms of treatment resistance in head and neck squamous cell carcinoma (HNSCC) are not well characterized. In this study, HNSCC tumors from a cohort of prospectively enrolled subjects on an ongoing tissue banking study were divided into those that persisted or recurred locoregionally (n=23) and...

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Udgivet i:Oncotarget
Main Authors: Ow, Thomas J., Fulcher, Cory D., Thomas, Carlos, Broin, Pilib Ó, López, Andrea, Reyna, Denis E., Smith, Richard V., Sarta, Catherine, Prystowsky, Michael B., Schlecht, Nicolas F., Schiff, Bradley A., Rosenblatt, Gregory, Belbin, Thomas J., Harris, Thomas M., Childs, Geoffrey C., Kawachi, Nicole, Guha, Chandan, Gavathiotis, Evripidis
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355180/
https://ncbi.nlm.nih.gov/pubmed/30728900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26563
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