Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1

Mechanisms of treatment resistance in head and neck squamous cell carcinoma (HNSCC) are not well characterized. In this study, HNSCC tumors from a cohort of prospectively enrolled subjects on an ongoing tissue banking study were divided into those that persisted or recurred locoregionally (n=23) and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ow, Thomas J., Fulcher, Cory D., Thomas, Carlos, Broin, Pilib Ó, López, Andrea, Reyna, Denis E., Smith, Richard V., Sarta, Catherine, Prystowsky, Michael B., Schlecht, Nicolas F., Schiff, Bradley A., Rosenblatt, Gregory, Belbin, Thomas J., Harris, Thomas M., Childs, Geoffrey C., Kawachi, Nicole, Guha, Chandan, Gavathiotis, Evripidis
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355180/
https://ncbi.nlm.nih.gov/pubmed/30728900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26563
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