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CSF1R antagonism limits local restimulation of antiviral CD8(+) T cells during viral encephalitis
BACKGROUND: Microglia are resident macrophages of the central nervous system (CNS) locally maintained through colony-stimulating factor 1 receptor (CSF1R) signaling. Microglial depletion via CSF1R inactivation improves cognition in mouse models of neuroinflammation, but limits virologic control in t...
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| Publicat a: | J Neuroinflammation |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6354430/ https://ncbi.nlm.nih.gov/pubmed/30704498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1397-4 |
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