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CD40-CD40 Ligand Interactions Promote Trafficking of CD8(+) T Cells into the Brain and Protection against West Nile Virus Encephalitis

Recent studies have established a protective role for T cells during primary West Nile virus (WNV) infection. Binding of CD40 by CD40 ligand (CD40L) on activated CD4(+) T cells provides an important costimulatory signal for immunoglobulin class switching, antibody affinity maturation, and priming of...

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Detalhes bibliográficos
Main Authors: Sitati, Elizabeth, McCandless, Erin E., Klein, Robyn S., Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045405/
https://ncbi.nlm.nih.gov/pubmed/17626103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00941-07
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