Skeletal muscle antagonizes antiviral CD8(+) T cell exhaustion

CD8(+) T cells become functionally impaired or “exhausted” in chronic infections, accompanied by unwanted body weight reduction and muscle mass loss. Whether muscle regulates T cell exhaustion remains incompletely understood. We report that mouse skeletal muscle increased interleukin (IL)–15 product...

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Vydáno v:Sci Adv
Hlavní autoři: Wu, Jingxia, Weisshaar, Nina, Hotz-Wagenblatt, Agnes, Madi, Alaa, Ma, Sicong, Mieg, Alessa, Hering, Marvin, Mohr, Kerstin, Schlimbach, Tilo, Borgers, Helena, Cui, Guoliang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7292629/
https://ncbi.nlm.nih.gov/pubmed/32582853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba3458
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