Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

BACKGROUND: Adenylate kinase 4 (AK4) has been identified as a biomarker of metastasis in lung cancer. However, the impacts of AK4 on metabolic genes and its translational value for drug repositioning remain unclear. METHODS: Ingenuity upstream analyses were used to identify potential transcription f...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Jan, Yi-Hua, Lai, Tsung-Ching, Yang, Chih-Jen, Lin, Yuan-Feng, Huang, Ming-Shyan, Hsiao, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352453/
https://ncbi.nlm.nih.gov/pubmed/30696468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0698-5
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